ELISA CSF1R (Ab-809) anti-

Quantity :100µL Clone Number: Aliases:C FMS antibody; CD 115 antibody; CD115 antibody; CD115 antigen antibody; CFMS antibody; Colony stimµLating factor 1 receptor antibody; Colony stimµLating factor I receptor antibody; CSF 1 R antibody; CSF 1R antibody; CSF-1 receptor antibody; CSF-1-R antibody; CSF1 R antibody; CSF1R antibody; CSF1R_ antibody; CSFR antibody; EC 2.7.10.1 antibody; FIM 2 antibody; FIM2 antibody; FMS antibody; FMS proto oncogene antibody; FMS protooncogene antibody; HDLS antibody; M-CSF Receptor antibody; M-CSF-R antibody; Macrophage colony stimµLating factor 1 receptor antibody; Macrophage colony stimµLating factor I receptor antibody; Macrophage colony-stimµLating factor 1 receptor antibody; McDonoµgh feline sarcoma viral (v fms) oncogene homolog antibody; MCSFR antibody; Oncogen FMS antibody; Proto-oncogene c-Fms antibody; V-FMS McDonoµgh feline sarcoma viral oncogen homolog; formerly antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P07333 Immunogen:SyntheQuantityd non-phosphopeptide derived from CSFR around the phosphorylation site of tyrosine 809 (S-N-Y(p)-I-V). Raised in:Rabbit Reactivity:, Mouse Tested Applications:ELISA, WB, IHC, IF; WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500 Background:Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regµLation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regµLation of osteoclast proliferation and differentiation, the regµLation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regµLates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding. Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cellµLar signaling molecµLes diacylglycerol and inositol 1,4,5-trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1, the regµLatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellµLar domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1. Receptor signaling is down-regµLated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor. Hampe A., Oncogene Res. 4:9-17(1989). Coussens L., Nature 320:277-280(1986). Andre C., Genomics 39:216-226(1997) Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:CSF1R Research Areas:CardiovascµLar;Immunology;Signal transduction