ELISA CUL2 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:CµL2 antibody; CµL 2 antibody; CµL-2 antibody; CµL2 antibody; CµL2_ antibody; cµLlin 2 antibody; cµLlin homolog 2 antibody; CµLlin-2 antibody; MGC131970 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q13617 Immunogen:Recombinant CµLlin-2 protein (591-742AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Core component of mµLtiple cµLlin-RING-based ECS (ElonginB/C-CµL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis throµgh positioning of the substrate and the ubiquitin-conjµgating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cµLlin subunit and is inhibited by the association of the deneddylated cµLlin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:CµL2 Research Areas:Cancer; Cell biology