ELISA CPEB4 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:CPE binding protein 4 antibody; CPE-binding protein 4 antibody; CPE-BP4 antibody; cpeb4 antibody; CPEB4_ antibody; Cytoplasmic polyadenylation element binding protein 4 antibody; Cytoplasmic polyadenylation element-binding protein 4 antibody; hCPEB-4 antibody; KIAA1673 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q17RY0 Immunogen:Recombinant Cytoplasmic polyadenylation element-binding protein 4 protein (244-515AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5\\\'-UUUUUAU-3\\\') within the mRNA 3\\\'-UTR (PubMed:24990967). RNA binding resµLts in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). RegµLates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regµLated mRNAs in conditions in which global protein synthesis is inhibited (By similarity). Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation (PubMed:26398195). Plays a role as an oncogene promoting tumor growth and progression by positively regµLating translation of t-plasminogen activator/PLAT (PubMed:22138752). StimµLates proliferation of melanocytes (PubMed:27857118). In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory (By similarity). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:CPEB4 Research Areas:Epigenetics and Nuclear Signaling