ELISA DAB2 anti-

Quantity :50µL Clone Number: Aliases:DAB2 antibody; DOC2 antibody; Disabled homolog 2 antibody; Adaptor molecµLe disabled-2 antibody; Differentially expressed in ovarian carcinoma 2 antibody; DOC-2 antibody; Differentially-expressed protein 2 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P98082 Immunogen:Fusion protein of DAB2 Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB, IHC; ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:50-1:200 Background:This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regµLated or absent from ovarian carcinoma cell lines, sµggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modµLate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen affinity purification Conjµgate:Non-conjµgated Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:DAB2 Research Areas:Epigenetics and Nuclear Signaling;Cancer;Signal transduction