ELISA CSK anti-
Quantity :100µL
Clone Number:
Aliases:C SRC antibody; C SRC kinase antibody; C src Tyrosine Kinase antibody; C-SRC kinase antibody; c-src tyrosine kinase antibody; Csk A antibody; CSK antibody; CSK_ antibody; CYTOPLASMIC TYROSINE KINASE antibody; EC 2.7.10.2 antibody; MGC112926 antibody; MGC117393 antibody; MGC154049 antibody; P60 Src antibody; Protein tyrosine kinase CYL antibody; Protein-tyrosine kinase CYL antibody; Proto oncogene tyrosine protein kinase antibody; Tyrosine protein kinase CSK antibody; Tyrosine-protein kinase CSK antibody; zgc:154049 antibody
Product Type:Polyclonal Antibody
Immunogen Species:Homo sapiens ()
UniProt ID:P41240
Immunogen:SyntheQuantityd peptide derived from internal of CSK.
Raised in:Rabbit
Reactivity:, Mouse, Rat
Tested Applications:ELISA, WB, IF; WB:1:500-1:3000, IF:1:100-1:500
Background:Non-receptor tyrosine-protein kinase that plays an important role in the regµLation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecµLar interactions between the phosphotyrosine tail and the SH2 domain that resµLt in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.
Partanen J., Oncogene 6:2013-2018(1991).
Braeuninger A., Proc. Natl. Acad. Sci. U.S.A. 88:10411-10415(1991).
Brauninger A., Gene 110:205-211(1992).
Clonality:Polyclonal
Isotype:IgG
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Conjµgate:Non-conjµgated
Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form:liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:CSK
Research Areas:Signal transduction
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