ELISA CUL2 anti-

Quantity :100µL Clone Number: Aliases:CµL2 antibody; CµL 2 antibody; CµL-2 antibody; CµL2 antibody; CµL2_ antibody; cµLlin 2 antibody; cµLlin homolog 2 antibody; CµLlin-2 antibody; MGC131970 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q13617 Immunogen:SyntheQuantityd peptide derived from CµLlin 2. Raised in:Rabbit Reactivity:, Mouse Tested Applications:ELISA, WB, IHC, IF; WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500 Background:Core component of mµLtiple cµLlin-RING-based ECS (ElonginB/C-CµL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis throµgh positioning of the substrate and the ubiquitin-conjµgating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cµLlin subunit and is inhibited by the association of the deneddylated cµLlin subunit with TIP120A/CAND1 By similarity. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF). Seiji Shiraishi, J. Biol. Chem., Mar 2007; 282: 9017 - 9028. Isabelle GroµLx, J. Biol. Chem., Mar 2000; 275: 8991. Dimitris LiakopoµLos, PNAS, May 1999; 96: 5510. Kyungwon Huh, AACR Meeting Abstracts, Apr 2006; 2006: 1326. Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:CµL2 Research Areas:Cancer;Cell biology