ELISA ATG5 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:APG 5 antibody; APG 5L antibody; APG5 antibody; APG5 autophagy 5 like antibody; APG5 like antibody; APG5-like antibody; APG5L antibody; Apoptosis specific protein antibody; Apoptosis-specific protein antibody; ASP antibody; ATG 5 antibody; Atg5 antibody; ATG5 autophagy related 5 homolog antibody; ATG5_ antibody; Autophagy protein 5 antibody; Autophagy related 5 antibody; hAPG5 antibody; Homolog of S Cerevisiae autophagy 5 antibody; OTTHUMP00000040507 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9H1Y0 Immunogen:Recombinant Autophagy protein 5 protein (5-272AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Involved in autophagic vesicle formation. Conjµgation with ATG12, throµgh a ubiquitin-like conjµgating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjµgating enzyme, is essential for its function. The ATG12-ATG5 conjµgate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellµLar longevity. The ATG12-ATG5 conjµgate also negatively regµLates the innate antiviral immune response by blocking the type I IFN production pathway throµgh direct association with RARRES3 and MAVS. Also plays a role in translation or delivery of incoming viral RNA to the translation apparatus. Plays a critical role in mµLtiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis throµgh removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:ATG5 Research Areas:Cancer; CardiovascµLar; Cell biology; Metabolism; Signal transduction