ELISA CLDN1 (Ab-210) anti-

Quantity :100µL Clone Number: Aliases:Claudin-1 antibody; Claudin1 antibody; CLD 1 antibody; CLD1 antibody; CLD1_ antibody; CLDN 1 antibody; Cldn1 antibody; ILVASC antibody; SEMP 1 antibody; SEMP1 antibody; Senescence associated epithelial membrane protein 1 antibody; Senescence associated epithelial membrane protein antibody; Senescence-associated epithelial membrane protein antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O95832 Immunogen:SyntheQuantityd non-phosphopeptide derived from Claudin 1 around the phosphorylation site of tyrosine 210 (G-K-D-Y(p)-V). Raised in:Rabbit Reactivity:, Mouse Tested Applications:ELISA, WB; WB:1:500-1:3000 Background:Claudins function as major constituents of the tight junction complexes that regµLate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecµLes. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellµLar diffusion of small molecµLes throµgh tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss throµgh the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (). CLDN1 acts as a coreceptor for HCV entry into hepatic cells. Swisshelm K.L., Gene 226:285-295(1999). Halford S., Cytogenet. Cell Genet. 88:217-217(2000). Kraemer F., Hum. Genet. 107:249-256(2000). Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:CLDN1 Research Areas:Signal transduction