ELISA COL4A2 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:Canstatin antibody; CO4A2_ antibody; COL4A 2 antibody; Col4a2 antibody; Collagen alpha 2(IV) chain antibody; Collagen; type IV; alpha 2 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P08572 Immunogen:Recombinant Collagen alpha-2(IV) chain protein (1493-1712AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Type IV collagen is the major structural component of glomerµLar basement membranes (GBM), forming a \\\'chicken-wire\\\' meshwork together with laminins, proteoglycans and entactin/nidogen. Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:COL4A2 Research Areas:CardiovascµLar; Signal transduction