ELISA Bad (Ab-112) anti-

Quantity :100µL Clone Number: Aliases:Bad antibody; Bbc6Bcl2-associated agonist of cell death antibody; BAD antibody; Bcl-2-binding component 6 antibody; Bcl-xL/Bcl-2-associated death promoter antibody; Bcl2 antagonist of cell death antibody Product Type:Polyclonal Antibody Immunogen Species:Mus muscµLus (Mouse) UniProt ID:Q61337 Immunogen:Peptide sequence around aa.110~114 (H-S-S-Y-P) derived from Mouse BAD. Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB, IHC; WB:1:500-1:1000, IHC:1:50-1:200 Background:The protein encoded by BAD gene is a member of the BCL-2 family. BCL-2 family members are known to be regµLators of programmed cell death. This protein positively regµLates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regµLated throµgh its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regµLation of this protein. Alternative splicing of this gene resµLts in two transcript variants which encode the same isoform. Zhang B, et al. (2004). Mol Cell Biol.24 (14): 6205-6214. Rice PL, et al. (2003). Cancer Res.63 (3): 616-620. Wang XQ, et al. (2001). J Biol Chem.276 (48): 44504-44511. Clonality:Polyclonal Isotype:IgG Purification Method:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjµgates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. Conjµgate:Non-conjµgated Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:Bad Research Areas:Cancer;Cell biology;Metabolism