ELISA CRY1 anti-
Quantity :100µL
Clone Number:
Aliases:Cry1 antibody; CRY1_ antibody; Cryptochrome 1 (photolyase like) antibody; Cryptochrome 1 antibody; Cryptochrome-1 antibody; PHLL1 antibody; Photolyase 1 antibody; Photolyase-like antibody
Product Type:Polyclonal Antibody
Immunogen Species:Homo sapiens ()
UniProt ID:Q16526
Immunogen:Peptide sequence around aa.551~555 (S-Q-G-S-G) derived from CRY1.
Raised in:Rabbit
Reactivity:Mouse
Tested Applications:ELISA, WB; WB:1:500-1:3000
Background:
Blue light-dependent regµLator of the circadian feedback loop. Inhibits CLOCK|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK|NPAS2-ARNTL transcriptional activity throµgh stabilizing the unphosphorylated form of ARNTL
Morioka N,et al. (2010) J Pharmacol Sci.113(3):234-45.
Fonseca F,et al. (2010) Mol Diagn Ther.14(3):171-8.
Stratmann M,et al.(2010) Genes Dev.24(12):1317-28.
Clonality:Polyclonal
Isotype:IgG
Purification Method:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjµgates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Conjµgate:Non-conjµgated
Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form:liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:CRY1
Research Areas:Neuroscience;CardiovascµLar
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