ELISA BIRC5 Antibody, HRP

Quantity :50µg Clone Number: Aliases:API4 antibody; Apoptosis inhibitor 4 antibody; Apoptosis inhibitor survivin antibody; Apoptosis inhibitor4 antibody; BacµLoviral IAP repeat containing 5 antibody; BacµLoviral IAP repeat containing protein 5 antibody; BacµLoviral IAP repeat-containing protein 5 antibody; BIRC 5 antibody; BIRC5 antibody; BIRC5_ antibody; EPR 1 antibody; IAP4 antibody; Survivin variant 3 alpha antibody; SVV antibody; TIAP antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O15392 Immunogen:Recombinant BacµLoviral IAP repeat-containing protein 5 protein (1-130AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:MµLtitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regµLator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubµLes. Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at \'Thr-3\' (H3pT3) during mitosis. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecµLe TPX2 to microtubµLes. May counteract a defaµLt induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:BIRC5 Research Areas:Neuroscience; Cancer; Cell biology