ELISA DACH1 Antibody, FITC

Quantity :50µg Clone Number: Aliases:DACH antibody; Dach1 antibody; DACH1_ antibody; Dachshund family transcription factor 1 antibody; dachshund homolog 1 (Drosophila) antibody; Dachshund homolog 1 antibody; Dachsund homolog 1 antibody; FLJ10138 antibody; OTTHUMP00000018494 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9UI36 Immunogen:Recombinant Dachshund homolog 1 protein (166-369AA) Raised in:Rabbit Reactivity: Tested Applications: Background:Transcription factor that is involved in regµLation of organogenesis. Seems to be a regµLator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation throµgh recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regµLating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling throµgh interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:FITC Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:DACH1 Research Areas:Epigenetics and Nuclear Signaling; Cancer