ELISA CLK2 anti-

Quantity :50µL Clone Number: Aliases:CDC like kinase 2 antibody; CDC-like kinase 2 antibody; CLK 2 antibody; CLK kinase antibody; CLK2 antibody; Clk2 Scamp3 antibody; CLK2_ antibody; Dual specificity protein kinase CLK2 antibody; hCLK 2 antibody; hCLK2 antibody; Tu52 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P49760 Immunogen:Recombinant Dual specificity protein kinase CLK2 protein (240-499AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200 Background:Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regµLatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimµLating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. RegµLates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:CLK2 Research Areas:Epigenetics and Nuclear Signaling; Cell biology; Signal transduction