ELISA CH25H Antibody, FITC
Quantity :50µg
Clone Number:
Aliases:CH25H antibody; Cholesterol 25-hydroxylase antibody; EC 1.14.99.38 antibody; Cholesterol 25-monooxygenase antibody; h25OH antibody
Product Type:Polyclonal Antibody
Immunogen Species:Homo sapiens ()
UniProt ID:O95992
Immunogen:Recombinant Cholesterol 25-hydroxylase protein (142-272AA)
Raised in:Rabbit
Reactivity:
Tested Applications:
Background:Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes (PubMed:9852097). Plays a key role in cell positioning and movement in lymphoid tissues: 25-hydroxycholesterol is an intermediate in biosynthesis of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC), an oxysterol that acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells. May play an important role in regµLating lipid metabolism by synthesizing a corepressor that blocks sterol regµLatory element binding protein (SREBP) processing. In testis, production of 25-hydroxycholesterol by macrophages may play a role in Leydig cell differentiation.
Clonality:Polyclonal
Isotype:IgG
Purification Method:>95%, Protein G purified
Conjµgate:FITC
Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:CH25H
Research Areas:Cancer; CardiovascµLar; Cell biology; Metabolism
Our latest content
Check out what's new in our company !
Your Dynamic Snippet will be displayed here... This message is displayed because you did not provide both a filter and a template to use.