ELISA ALOX12B Antibody, HRP

Quantity :50µL Clone Number: Aliases:ALOX12B antibody; Arachidonate 12-lipoxygenase antibody; 12R-type antibody; 12R-LOX antibody; 12R-lipoxygenase antibody; EC 1.13.11.- antibody; Epidermis-type lipoxygenase 12 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O75342 Immunogen:Recombinant Arachidonate 12-lipoxygenase, 12R-type protein (484-663AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12R)-hydroperoxyeicosatetraenoic acid/(12R)-HPETE and minor stereoisomers. In the skin, acts upstream of ALOXE3 on the lineolate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjµgation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. May also play a role in the regµLation of the expression of airway mucins. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:ALOX12B Research Areas:CardiovascµLar; Cell biology; Metabolism; Signal transduction