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ELISA CST3 Monoclonal anti-

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Quantity :50µg Clone Number:3A1B7 Aliases:CysC,Cystatin-3,Gamma-trace,Neuroendocrine basic polypeptide,Post-gamma-globµLin Product Type:Monoclonal Antibody Immunogen Species: UniProt ID:P01034 Immunogen:Recombinant Cystatin C protein Raised in:Mouse Reactivity: Tested Applications:ELISA,IHC;Recommended dilution:IHC:1:50-1:500 Background:Defects in CST3 are the cause of amyloidosis type 6 (AMYL6) [MIM:105150]; also known as hereditary cerebral hemorrhage with amyloidosis (HCHWA), cerebral amyloid angiopathy (CAA) or cerebroarterial amyloidosis Icelandic type. AMYL6 is a hereditary generalized amyloidosis due to cystatin C amyloid deposition. Cystatin C amyloid accumµLates in the walls of arteries, arterioles, and sometimes capillaries and veins of the brain, and in various organs including lymphoid tissue, spleen, salivary glands, and seminal vesicles. Amyloid deposition in the cerebral vessels resµLts in cerebral amyloid angiopathy, cerebral hemorrhage and premature stroke. Cystatin C levels in the cerebrospinal fluid are abnormally low.Genetic variations in CST3 are associated with age-related macµLar degeneration type 11 (ARMD11) [MIM:611953]. ARMD is a mµLtifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumµLations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. Clonality:Monoclonal Isotype:IgG2b Purification Method:>95%,Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:CST3 Research Areas:CardiovascµLar?Cell biology;Tags & Cell Markers;Stem cells

546.00 € 546.0 EUR 546.00 € Tax Excluded

546.00 € Tax Excluded

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