ELISA HOMER1 Antibody, FITC

Quantity :50µg Clone Number: Aliases:HOME1_ antibody; Homer antibody; HOMER 1A antibody; HOMER 1B antibody; HOMER 1C antibody; Homer homolog 1 (Drosophila) antibody; homer homolog 1 antibody; Homer protein homolog 1 antibody; homer scaffolding protein 1 antibody; Homer; Drosophila; homolog of; 1 antibody; Homer; neuronal immediate early gene; 1 antibody; Homer-1 antibody; Homer1 antibody; HOMER1A antibody; HOMER1B antibody; HOMER1C antibody; SYN47 antibody; Ves 1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q86YM7 Immunogen:Recombinant Homer protein homolog 1 protein (1-354AA) Raised in:Rabbit Reactivity: Tested Applications: Background:Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellµLar calcium release. May also couple GRM1 to PI3 kinase throµgh its interaction with AGAP2. Isoform 1 regµLates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regµLate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines (By similarity). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:FITC Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:HOMER1 Research Areas:Neuroscience