ELISA CASP3 anti-

Quantity:100µg Purification:protein A+G purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Mouse Clonality:monoclonal Clone ID:2G7 Isotype:IgG1 Storage:0.01MPBS pH 7.4,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Caspase 3, also named as CPP32, SCA-1 and Apopain, belongs to the peptidase C14A family. Caspase 3 is involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase(PARP) at a '216-Asp-|-Gly-217' bond. Caspase 3 cleaves and activates sterol regµLatory element binding proteins(SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6,-7 and-9. Caspase 3 is involved in the cleavage of huntingtin. Caspase 3 can also form heterocomplex with other proteins and performs MW of 50-70 kDa. This antibody can recognize p17, p19 and p32 of Caspase 3. Immunogen:caspase 3, apoptosis-related cysteine peptidase Synonyms:Apopain, CASP 3, CASP3, Caspase 3, Caspase 3/p17, Caspase3, CPP 32, CPP32, CPP32B, Cysteine protease CPP32, Protein Yama, SCA 1, SREBP cleavage activity 1 Observed MW:32-35 kDa, 19 kDa, 17 kDa Uniprot ID:P42574 Reactivity:, Mouse, Rat Tested Application:ELISA, IHC, WB,IF Recommended dilution:WB: 1:500-1:2000; IHC: 1:50-1:300; IF: 1:50-1:200 Gene ID:836 Research Area:Cancer, Metabolism, Neuroscience