ELISA CDK5RAP3 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation(PubMed:12054757, PubMed:12737517). Negatively regµLates NF-kappa-B-mediated gene transcription throµgh the control of RELA phosphorylation(PubMed:17785205, PubMed:20228063). Also regµLates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint(PubMed:15790566, PubMed:19223857). Throµgh its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation(PubMed:16173922). May play a role in the unfolded protein response, mediating the ufmylation of mµLtiple proteins in response to endoplasmic reticµLum stress(PubMed:23152784). May also play a role in the rupture of the nuclear envelope during apoptosis(PubMed:23478299). May regµLate MAPK14 activity by regµLating its dephosphorylation by PPM1D/WIP1(PubMed:21283629). (Microbial infection) May be negatively regµLated by hepatitis B virus large envelope protein mutant pre-s2 to promote mitotic entry. Immunogen:CDK5 regµLatory subunit associated protein 3 Synonyms:IC53, Observed MW:65 kDa Uniprot ID:Q96JB5 Reactivity:, Mouse, Rat Tested Application:ELISA, WB, IHC, IF, FC Recommended dilution:WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200 Gene ID:80279 Research Area:Cell Division and Proliferation