ELISA CD46 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimµLatory factor for T-cells which induces the differentiation of CD4+ into T-regµLatory 1 cells. T-regµLatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thoµght to prevent autoimmunity. (Microbial infection) A number of viral and bacterial pathogens seem to bind MCP in order to exploit its immune regµLation property and directly induce an immunosuppressive phenotype in T-cells. Acts as a receptor for adenovirus subgroup B2 and Ad3, cµLtured measles virus and herpesvirus 6(PubMed:10972291, PubMed:12663806, PubMed:12724329, PubMed:12915534, PubMed:14566335, PubMed:15047806, PubMed:15078926, PubMed:15919905, PubMed:16254377). May act as a receptor for pathogenic bacteria Neisseria and Streptococcus pyogenes(PubMed:7708671, PubMed:9379894, PubMed:11260136, PubMed:11971006). Immunogen:CD46 molecµLe, complement regµLatory protein Synonyms:MCP, MIC10 Observed MW:50-56 kDa Uniprot ID:P15529 Reactivity:, Mouse Tested Application:ELISA, WB, IP Recommended dilution:WB: 1:500-1:1000; IP: 1:200-1:1000 Gene ID:4179 Research Area:Immunology, Metabolism