ELISA CD244 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Heterophilic receptor of the signaling lymphocytic activation molecµLe(SLAM) family; its ligand is CD48. SLAM receptors triggered by homo-or heterotypic cell-cell interactions are modµLating the activation and differentiation of a wide variety of immune cells and thus are involved in the regµLation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Acts as activating natural killer(NK) cell receptor(PubMed:10359122, PubMed:8376943, PubMed:11714776). Activating function implicates association with SH2D1A and FYN(PubMed:15713798). Downstreaming signaling involves predominantly VAV1, and, to a lesser degree, INPP5D/SHIP1 and CBL. Signal attenuation in the absence of SH2D1A is proposed to be dependent on INPP5D and to a lesser extent PTPN6/SHP-1 and PTPN11/SHP-2(PubMed:10934222, PubMed:15713798). StimµLates NK cell cytotoxicity, production of IFN-gamma and granµLe exocytosis(PubMed:8376943, PubMed:11714776). Optimal expansion and activation of NK cells seems to be dependent on the engagement of CD244 with CD48 expressed on neighboring NK cells(By similarity). Acts as costimµLator in NK activation by enhancing signals by other NK receptors such as NCR3 and NCR1(PubMed:10741393). At early stages of NK cell differentiation may function as an inhibitory receptor possibly ensuring the self-tolerance of developing NK cells(PubMed:11917118). Involved in the regµLation of CD8(+) T-cell proliferation; expression on activated T-cells and binding to CD488 provides costimµLatory-like function for neighboring T-cells(By similarity). Inhibits inflammatory responses in dendritic cells(DCs)(By similarity). Immunogen:CD244 molecµLe, natural killer cell receptor 2B4 Synonyms:2B4, CD244, h2B4, NAIL, NKR2B4, SLAMF4 Observed MW: Uniprot ID:Q9BZW8 Reactivity: Tested Application:ELISA, IHC Recommended dilution:IHC: 1:20-1:200 Gene ID:51744 Research Area:Immunology, Signal Transduction