ELISA CALCOCO2 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Xenophagy-specific receptor required for autophagy-mediated intracellµLar bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting galectin-8-associated bacteria for autophagy(PubMed:22246324). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regµLating pathogen-containing autophagosome maturation(PubMed:23022382, PubMed:25771791). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regµLation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C(PubMed:23022382, PubMed:25771791). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regµLate constitutive secretion(PubMed:17635994). Immunogen:calcium binding and coiled-coil domain 2 Synonyms:NDP52 Observed MW:52 kDa Uniprot ID:Q13137 Reactivity:, Mouse, Rat Tested Application:ELISA, WB, IHC, IP Recommended dilution:WB: 1:500-1:2000; IP: 1:500-1:1000; IHC: 1:50-1:200 Gene ID:10241 Research Area:Signal Transduction, Metabolism