ELISA CACNA1S anti-
Quantity:100µg
Purification:Immunogen affinity purified
Form:liquid
Purity:?95% as determined by SDS-PAGE
Host:Rabbit
Clonality:polyclonal
Clone ID:
Isotype:IgG
Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)
Background:Voltage-sensitive calcium channels(VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1S gives rise to L-type calcium currents. Long-lasting(L-type) calcium channels belong to the 'high-voltage activated'(HVA) group. They are blocked by dihydropyridines(DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA(omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA(omega-CTx-GVIA) and omega-agatoxin-IVA(omega-Aga-IVA). Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle.
Immunogen:calcium channel, voltage-dependent, L type, alpha 1S subunit
Synonyms:CACH1, CACN1, CACNL1A3
Observed MW:200-220kd
Uniprot ID:Q13698
Reactivity:
Tested Application:ELISA, WB, IHC
Recommended dilution:WB: 1:500-1:2000; IHC: 1:20-1:200
Gene ID:779
Research Area:Neuroscience