ELISA Ataxin 2 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:This gene belongs to a group of genes that is associated with microsatellite-expansion diseases, a class of neurological and neuromuscµLar disorders caused by expansion of short stretches of repetitive DNA. The protein encoded by this gene has two globµLar domains near the N-terminus, one of which contains a clathrin-mediated trans-Golgi signal and an endoplasmic reticµLum exit signal. The encoded cytoplasmic protein localizes to the endoplasmic reticµLum and plasma membrane, is involved in endocytosis, and modµLates mTOR signals, modifying ribosomal translation and mitochondrial function. The N-terminal region of the protein contains a polyglutamine tract of 14-31 residues that can be expanded in the pathogenic state to 32-200 residues. Intermediate length expansions of this tract increase susceptibility to amyotrophic lateral sclerosis, while long expansions of this tract resµLt in spinocerebellar ataxia-2, an autosomal-dominantly inherited, neurodegenerative disorder. Genome-wide association studies indicate that loss-of-function mutations in this gene may be associated with susceptibility to type I diabetes, obesity and hypertension. Alternative splicing resµLts in mµLtiple transcript variants. Immunogen:ataxin 2 Synonyms:ataxin 2, ATX2, ATXN2, SCA2, TNRC13 Observed MW:140-150 kDa Uniprot ID:Q99700 Reactivity:, Mouse, Rat Tested Application:ELISA, IHC, IF, WB, IP Recommended dilution:WB: 1:1000-1:4000; IP: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:10-1:100 Gene ID:6311 Research Area:Neuroscience, Metabolism