ELISA ARHGEF5 anti-
Quantity:100µg
Purification:Immunogen affinity purified
Form:liquid
Purity:?95% as determined by SDS-PAGE
Host:Rabbit
Clonality:polyclonal
Clone ID:
Isotype:IgG
Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)
Background:Guanine nucleotide exchange factor which activates Rho GTPases(PubMed:15601624). Strongly activates RHOA(PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1(By similarity). Involved in regµLation of cell shape and actin cytoskeletal organization(PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia(PubMed:14662653). Required for SRC-induced podosome formation(By similarity). Involved in positive regµLation of immature dendritic cell migration(By similarity).
Immunogen:Rho guanine nucleotide exchange factor(GEF) 5
Synonyms:TIM
Observed MW:60 kDa
Uniprot ID:Q12774
Reactivity:, Mouse, Rat
Tested Application:ELISA, WB, IHC, IP
Recommended dilution:WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200
Gene ID:7984
Research Area:Signal Transduction