ELISA APC anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regµLator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor(HGF)-induced cell migration. Required for MMP9 up-regµLation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubµLes at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubµLe stabilization. Immunogen:adenomatous polyposis coli Synonyms:adenomatous polyposis coli, APC, BTPS2, Deleted in polyposis 2.5, DP2, DP2.5, DP3, GS, Protein APC Observed MW:300 kDa Uniprot ID:P25054 Reactivity:, Mouse Tested Application:ELISA, WB, IHC Recommended dilution:WB: 1:500 - 1:2000; IHC: 1:20-1:200 Gene ID:324 Research Area:Cancer, Cell Division and Proliferation, CardiovascµLar, Signal Transduction