ELISA ALCAM anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Cell adhesion molecµLe that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts(PubMed:7760007, PubMed:15496415, PubMed:15048703, PubMed:16352806, PubMed:23169771, PubMed:24945728). Promotes T-cell activation and proliferation via its interactions with CD6(PubMed:15048703, PubMed:16352806, PubMed:24945728). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6(PubMed:15294938, PubMed:16352806). Mediates homotypic interactions with cells that express ALCAM(PubMed:15496415, PubMed:16352806). Required for normal hematopoietic stem cell engraftment in the bone marrow(PubMed:24740813). Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction(PubMed:23169771). Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions(PubMed:15496415, PubMed:23169771). Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation(By similarity). Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM. Mediates outgrowth and pathfinding for retinal ganglion cell axons(By similarity). Isoform 3: Inhibits activities of membrane-bound isoforms by competing for the same interaction partners. Inhibits cell attachment via homotypic interactions. Promotes endothelial cell migration. Inhibits endothelial cell tube formation. Immunogen:activated leukocyte cell adhesion molecµLe Synonyms:ALCAM, CD166, CD166 antigen, FLJ38514, MEMD Observed MW:110 kDa Uniprot ID:Q13740 Reactivity: Tested Application:ELISA, IHC, WB Recommended dilution:WB: 1:200-1:2000; IHC: 1:20-1:200 Gene ID:214 Research Area:Stem Cells, Immunology, Signal Transduction, Developmental biology