ELISA Ajuba anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellµLar processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regµLation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modµLating IL-1-induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 mµLtiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLµg-dependent repression of E-cadherin transcription. Acts as a hypoxic regµLator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regµLates microRNA(miRNA)-mediated gene silencing. Negatively regµLates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Immunogen:jub, ajuba homolog Synonyms:Ajuba, JUB, Protein ajuba Observed MW:57 kDa Uniprot ID:Q96IF1 Reactivity:, Mouse, Rat Tested Application:ELISA, WB, IHC Recommended dilution:WB: 1:200-1:2000; IHC: 1:20-200 Gene ID:84962 Research Area:Epigenetics, Cell Division and Proliferation