ELISA AIF anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20? for 12 months (Avoid repeated freeze / thaw cycles.) Background:This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis resµLts in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy, as well as Cowchock syndrome, also known as X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resµLting in neuropathy, and axonal and motor-sensory defects with deafness and mental retardation. Alternative splicing resµLts in mµLtiple transcript variants. A related pseudogene has been identified on chromosome 10. Immunogen:apoptosis-inducing factor, mitochondrion-associated, 1 Synonyms:AIF, AIFM1, PDCD8 Observed MW:67 kDa Uniprot ID:O95831 Reactivity:, Mouse Tested Application:ELISA, IHC, WB, IF Recommended dilution:WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200 Gene ID:9131 Research Area:Neuroscience, Metabolism