ELISA CBX2 anti-
Quantity :50µL
Clone Number:24A2
Aliases:Chromobox protein homolog 2, CBX2
Product Type:Recombinant Antibody
Immunogen Species:Homo sapiens ()
UniProt ID:Q14781
Immunogen:A syntheQuantityd peptide derived from CBX2
Raised in:
Reactivity:, Rat
Tested Applications:ELISA, WB; Recommended dilution: WB:1:500-1:2000
Background:Component of a Polycomb group (PcG) mµLtiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throµghout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:21282530). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3) (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity). Involved in sexual development, acting as activator of NR5A1 expression (PubMed:19361780). {ECO:0000250|UniProtKB:P30658, ECO:0000269|PubMed:19361780, ECO:0000269|PubMed:21282530}.
Clonality:Monoclonal
Isotype:Rabbit IgG
Purification Method:Affinity-chromatography
Conjµgate:Non-conjµgated
Buffer:Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:CBX2
Research Areas:Epigenetics and Nuclear Signaling