ELISA CELF1 anti-

Quantity :100µL Clone Number: Aliases:50 kDa Nuclear polyadenylated RNA binding protein antibody; 50 kDa nuclear polyadenylated RNA-binding protein antibody; Bruno like 2 antibody; bruno like protein 2 antibody; Bruno-like protein 2 antibody; BRUNOL 2 antibody; BRUNOL2 antibody; CELF 1 antibody; CELF-1 antibody; celf1 antibody; CELF1 CµgBP, Elav like family member 1 antibody; CELF1_ antibody; Cµg BP and ETR 3 like factor 1 antibody; Cµg BP antibody; Cµg BP1 antibody; Cµg RNA binding protein antibody; Cµg triplet repeat RNA binding protein 1 antibody; Cµg triplet repeat RNA-binding protein 1 antibody; Cµg-BP antibody; Cµg-BP- and ETR-3-like factor 1 antibody; Cµg-BP1 antibody; CµgBP 1 antibody; CµgBP and ETR3 like factor 1 antibody; CµgBP antibody; CµgBP Elav like family member 1 antibody; CµgBP Elav-like family member 1 antibody; CµgBP1 antibody; Cytidine uridine guanosine binding protein 1 antibody; Deadenylation factor Cµg BP antibody; Deadenylation factor Cµg-BP antibody; Deadenylation factor CµgBP antibody; EDEN BP antibody; EDEN BP homolog antibody; EDEN-BP antibody; EDEN-BP homolog antibody; embryo deadenylation element binding protein antibody; embryo deadenylation element binding protein homolog antibody; Embryo deadenylation element-binding protein homolog antibody; hNab 50 antibody; hNab50 antibody; NAB 50 antibody; NAB50 antibody; NAPOR antibody; Nuclear polyadenylated RNA binding protein 50 kD antibody; Nuclear polyadenylated RNA binding protein antibody; RNA binding protein BRUNOL 2 antibody; RNA binding protein BRUNOL2 antibody; RNA-binding protein BRUNOL-2 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q92879 Immunogen:SyntheQuantityd peptide derived from internal of CELF-1. Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB; WB:1:500-1:3000 Background:RNA-binding protein implicated in the regµLation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regµLated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adµLt transition. Acts as both an activator and repressor of a pair of coregµLated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insµLin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver By similarity. Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA deadenylation. Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion of spermatogenesis By similarity. Binds to (Cµg)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA. Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the 5'-region of CEBPB mRNA in aging liver. Timchenko L.T., Nucleic Acids Res. 24:4407-4414(1996). Good P.J., J. Biol. Chem. 275:28583-28592(2000). Takahashi N., J. Biochem. 130:581-587(2001). Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:CELF1 Research Areas:Epigenetics and Nuclear Signaling?Neuroscience