ELISA BRSK1 anti-

Quantity :100µL Clone Number: Aliases:BR serine/threonine kinase 1 antibody; BR serine/threonine protein kinase 1 antibody; BR serine/threonine-protein kinase 1 antibody; Brain selective kinase 1 antibody; Brain-specific serine/threonine-protein kinase 1 antibody; BRSK 1 antibody; Brsk1 antibody; BRSK1_ antibody; FLJ43009 antibody; hSAD1 antibody; KIAA1811 antibody; Protein kinase SAD1A antibody; SAD 1 antibody; SAD1 antibody; SAD1 homolog antibody; SAD1 kinase antibody; SAD1A antibody; SADB antibody; SadB kinase short isoform antibody; Serine/threonine kinase SAD B antibody; Serine/threonine-protein kinase SAD-B antibody; Synapses of Amphids Defective homolog antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q8TDC3 Immunogen:SyntheQuantityd peptide derived from internal of BRSK1. Raised in:Rabbit Reactivity:, Mouse Tested Applications:ELISA, WB; WB:1:500-1:3000 Background:Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regµLator of polarization of cortical neurons, probably by mediating phosphorylation of microtubµLe-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regµLates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regµLate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regµLator of centrosome duplication by mediating phosphorylation of gamma-tubµLin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubµLin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity throµgh phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C. Lizcano J.M., EMBO J. 23:833-843(2004). Lu R., J. Biol. Chem. 279:31164-31170(2004). Nagase T., DNA Res. 8:85-95(2001). Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:BRSK1 Research Areas:Cell biology