ELISA CALR anti-

Quantity :50µL Clone Number: Aliases:Autoantigen RO antibody; CALR antibody; CALR protein antibody; CALR_ antibody; CalregµLin antibody; CalreticµLin antibody; cC1qR antibody; CRP55 antibody; CRT antibody; CRTC antibody; Endoplasmic reticµLum resident protein 60 antibody; Epididymis secretory sperm binding protein Li 99n antibody; ERp60 antibody; FLJ26680 antibody; grp60 antibody; HACBP antibody; HEL S 99n antibody; RO antibody; Sicca syndrome antigen A (autoantigen Ro; calreticµLin) antibody; Sicca syndrome antigen A antibody; SSA antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P27797 Immunogen:Fusion protein of CALR Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB, IHC; ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:50-1:200 Background:CalreticµLin is a mµLtifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticµLum. It is also found in the nucleus, sµggesting that it may have a role in transcription regµLation. CalreticµLin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. CalreticµLin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticµLum where it may bind calcium. The amino terminus of calreticµLin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen affinity purification Conjµgate:Non-conjµgated Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:CALR Research Areas:Tags & Cell Markers