ELISA AOX1 anti-

Quantity :100µL Clone Number: Aliases:AOX1 antibody; AOAldehyde oxidase antibody; EC 1.2.3.1 antibody; Aldehyde oxidase 1 antibody; Azaheterocycle hydroxylase antibody; EC 1.17.3.- antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q06278 Immunogen:SyntheQuantityd peptide derived from internal of AOX1. Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB, IHC; WB:1:500-1:3000, IHC:1:50-1:100 Background:Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide and N-methylphthalazinium, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drµgs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrµgs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regµLation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecµLar oxygen. Also may catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis. Wright R.M., Proc. Natl. Acad. Sci. U.S.A. 90:10690-10694(1993). Wright R.M., Redox Rep. 3:135-144(1997). Hillier L.W., Nature 434:724-731(2005). Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:AOX1 Research Areas:Cancer;Metabolism;Signal transduction