ELISA CACNA1A anti-
Quantity :50µL
Clone Number:
Aliases:CACNA1A antibody; CACH4 antibody; CACN3 antibody; CACNL1A4 antibody; Voltage-dependent P/Q-type calcium channel subunit alpha-1A antibody; Brain calcium channel I antibody; BI antibody; Calcium channel antibody; L type antibody; alpha-1 polypeptide isoform 4 antibody; Voltage-gated calcium channel subunit alpha Cav2.1 antibody
Product Type:Polyclonal Antibody
Immunogen Species:Homo sapiens ()
UniProt ID:O00555
Immunogen:Synthetic peptide of CACNA1A
Raised in:Rabbit
Reactivity:
Tested Applications:ELISA, IHC; ELISA:1:1000-1:2000, IHC:1:15-1:50
Background:Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are mµLtisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas, the others act as auxiliary subunits regµLating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1A subunit, which is predominantly expressed in neuronal tissue. Mutations in this gene are associated with 2 neurologic disorders, familial hemiplegic migraine and episodic ataxia 2. This gene also exhibits polymorphic variation due to (CAG)n-repeats. MµLtiple transcript variants encoding different isoforms have been found for this gene. In one set of transcript variants, the (CAG)n-repeats occur in the 3' UTR, and are not associated with any disease. But in another set of variants, an insertion extends the coding region to include the (CAG)n-repeats which encode a polyglutamine tract. Expansion of the (CAG)n-repeats from the normal 4-16 to 21-28 in the coding region is associated with spinocerebellar ataxia 6.
Clonality:Polyclonal
Isotype:IgG
Purification Method:Antigen affinity purification
Conjµgate:Non-conjµgated
Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:CACNA1A
Research Areas:Neuroscience?Cancer;Metabolism