ELISA CBLC anti-

Quantity :50µL Clone Number: Aliases:CBLC antibody; CBL3 antibody; RNF57E3 ubiquitin-protein ligase CBL-C antibody; EC 2.3.2.27 antibody; RING finger protein 57 antibody; RING-type E3 ubiquitin transferase CBL-C antibody; SH3-binding protein CBL-3 antibody; SH3-binding protein CBL-C antibody; Signal transduction protein CBL-C antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9µLV8 Immunogen:Recombinant E3 ubiquitin-protein ligase CBL-C protein (245-474AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB, IHC; Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200 Background:Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjµgating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. RegµLator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimµLated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at \\\'Tyr-419\\\'. In collaboration with CD2AP may act as regµLatory checkpoint for Ret signaling by modµLating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:CBLC Research Areas:Epigenetics and Nuclear Signaling; Cancer