ELISA CDK12 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:arginine/serine-rich antibody; Cdc2 related kinase arginine/serine rich antibody; CDC2 related protein kinase 7 antibody; Cdc2-related kinase antibody; CDC2-related protein kinase 7 antibody; Cdk12 antibody; CDK12_ antibody; Cell division cycle 2 related protein kinase 7 antibody; Cell division cycle 2-related protein kinase 7 antibody; Cell division protein kinase 12 antibody; CRK7 antibody; CRKR antibody; CrkRS antibody; Cyclin-dependent kinase 12 antibody; EC 2.7.11.22 antibody; hCDK12 antibody; kiaa0904 antibody; Pksc antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9NYV4 Immunogen:Recombinant Cyclin-dependent kinase 12 protein (1309-1490AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regµLator of transcription elongation. RegµLates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates \'Ser-5\' in CTD repeats that are already phosphorylated at \'Ser-7\', but can also phosphorylate \'Ser-2\'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regµLation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:CDK12 Research Areas:Cancer; Signal transduction