ELISA CALCOCO1 anti-

Quantity :50µL Clone Number: Aliases:CALCOCO1 antibody; KIAA1536 antibody; PP13275 antibody; UNQ2436/PRO4996Calcium-binding and coiled-coil domain-containing protein 1 antibody; Calphoglin antibody; Coiled-coil coactivator protein antibody; Sarcoma antigen NY-SAR-3 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9P1Z2 Immunogen:Recombinant Calcium-binding and coiled-coil domain-containing protein 1 protein (462-691AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200 Background:Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters throµgh its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions (By similarity). In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:CALCOCO1 Research Areas:Epigenetics and Nuclear Signaling; Signal transduction