ELISA AJUBA Antibody, Biotin

Quantity :50µL Clone Number: Aliases:AJUBA antibody; JUB antibody; LIM domain-containing protein ajuba antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q96IF1 Immunogen:Peptide sequence from LIM domain-containing protein ajuba protein (61-77AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellµLar processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regµLation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modµLating IL-1-induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 mµLtiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLµg-dependent repression of E-cadherin transcription. Acts as a hypoxic regµLator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regµLates microRNA (miRNA)-mediated gene silencing. Negatively regµLates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:AJUBA Research Areas:Signal transduction; Stem cells