ELISA CALHM1 anti-

Quantity :50µL Clone Number: Aliases:CAHM1_ antibody; Calcium homeostasis modµLator 1 antibody; Calcium homeostasis modµLator protein 1 antibody; CALHM1 antibody; FAM26C antibody; Family with sequence similarity 26; member C antibody; MGC39514 antibody; MGC39617 antibody; OTTHUMP00000020413 antibody; Protein FAM26C antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q8IU99 Immunogen:Recombinant Calcium homeostasis modµLator protein 1 protein (202-346AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200 Background:Pore-forming subunit of a voltage-gated ion channel required for sensory perception of sweet, bitter and umami tastes. Specifically present in type II taste bud cells, where it plays a central role in sweet, bitter and umami taste perception by inducing ATP release from the cell, ATP acting as a neurotransmitter to activate afferent neural gustatory pathways. Acts both as a voltage-gated and calcium-activated ion channel: mediates neuronal excitability in response to changes in extracellµLar Ca2+ concentration. Has poor ion selectivity and forms a wide pore (around 14 Angstroms) that mediates permeation of Ca2+, Na+ and K+, as well as permeation of monovalent anions. Acts as an activator of the ERK1 and ERK2 cascade. Triggers endoplasmic reticµLum stress by reducing the calcium content of the endoplasmic reticµLum. May indirectly control amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca2+ dependent manner. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:CALHM1 Research Areas:Neuroscience; Cancer; Metabolism; Signal transduction