ELISA APAF1 anti-

Quantity :50µL Clone Number: Aliases:APAF 1 antibody; Apaf-1 antibody; APAF_ antibody; Apaf1 antibody; Apoptotic peptidase activating factor 1 antibody; Apoptotic protease activating factor 1 antibody; Apoptotic protease activating factor antibody; Apoptotic protease-activating factor 1 antibody; CED 4 antibody; CED4 antibody; KIAA0413 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O14727 Immunogen:Synthetic peptide of APAF1 Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, IHC; ELISA:1:1000-1:10000, IHC:1:25-1:100 Background:This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimµLates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing resµLts in several transcript variants encoding different isoforms. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen affinity purification Conjµgate:Non-conjµgated Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:APAF1 Research Areas:Cancer;Cell biology;Metabolism