ELISA CARD16 Antibody, Biotin

Quantity :50µL Clone Number: Aliases:CAR16_ antibody; CARD only domain-containing protein 1 antibody; CARD only protein antibody; CARD16 antibody; Caspase recruitment domain family, member 16 antibody; Caspase recruitment domain-containing protein 16 antibody; Caspase-1 dominant-negative inhibitor pseudo-ICE antibody; Caspase-1 inhibitor COP antibody; COP antibody; COP1 antibody; Pseudo interleukin 1 beta converting enzyme antibody; Pseudo interleukin-1 beta converting enzyme antibody; Pseudo interleukin-1beta converting enzyme antibody; PSEUDO-ICE antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q5EG05 Immunogen:Recombinant Caspase recruitment domain-containing protein 16 protein (1-197AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Caspase inhibitor. Acts as a regµLator of procaspase-1/CASP1 activation implicated in the regµLation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:CARD16 Research Areas:Cell biology