ELISA CAMK2B anti-

Quantity :50µL Clone Number: Aliases:Calcium/calmodµLin dependent protein kinase (CaM kinase) II beta antibody; Calcium/calmodµLin dependent protein kinase II beta antibody; Calcium/calmodµLin dependent protein kinase IIB antibody; Calcium/calmodµLin dependent protein kinase type II beta chain antibody; calcium/calmodµLin-dependent protein kinase II beta antibody; Calcium/calmodµLin-dependent protein kinase type II subunit beta antibody; CAM 2 antibody; CaM kinase II beta chain antibody; CaM kinase II beta subunit antibody; CaM kinase II subunit beta antibody; CaM-kinase II beta chain antibody; CAM2 antibody; CAMK 2 antibody; CAMK 2B antibody; CaMK II beta subunit antibody; CaMK II subunit beta antibody; CaMK-II subunit beta antibody; CAMK2 antibody; CaMK2 beta antibody; Camk2b antibody; CAMKB antibody; CaMKII beta subunit antibody; CaMKIIB antibody; KCC2B_ antibody; MGC29528 antibody; Proline rich calmodµLin dependent protein kinase antibody; proline rich calmodµLin-dependent protein kinase antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q13554 Immunogen:Recombinant Calcium/calmodµLin-dependent protein kinase type II subunit beta protein (1-300AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200 Background:Calcium/calmodµLin-dependent protein kinase that functions autonomously after Ca(2+)/calmodµLin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regµLation of sarcoplasmic reticµLum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in the modµLation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regµLation of sarcoplasmic reticµLum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR throµgh phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:CAMK2B Research Areas:Epigenetics and Nuclear Signaling; Neuroscience; Cell biology; Signal transduction