ELISA CAMK4 anti-

Quantity :50µL Clone Number: Aliases:Brain Ca(2+) calmodµLin dependent protein kinase type 4 antibody; Brain Ca(2+) calmodµLin dependent protein kinase type IV antibody; Brain Ca++-calmodµLin dependent protein kinase type IV antibody; Calcium / calmodµLin dependent protein kinase type 4 catalytic chain antibody; Calcium / calmodµLin dependent protein kinase type IV catalytic chain antibody; Calcium/calmodµLin dependent protein kinase IV antibody; Calcium/calmodµLin dependent protein kinase type IV antibody; Calcium/calmodµLin-dependent protein kinase type IV antibody; CAM kinase 4 antibody; CAM kinase GR antibody; CAM kinase IV antibody; CAM kinase-GR antibody; CaMK 4 antibody; CAMK GR antibody; CaMK IV antibody; Camk4 antibody; CaMKGR antibody; IV antibody; KCC4_ antibody; MGC36771 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q16566 Immunogen:Recombinant Calcium/calmodµLin-dependent protein kinase type IV protein (304-473AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB, IP; Recommended dilution: WB:1:1000-1:5000, IP:1:200-1:2000 Background:Calcium/calmodµLin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regµLates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regµLates the CD4+/CD8+ double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (throµgh the regµLation of CREB and MEF2). RegµLates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regµLation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on \\\'Ser-133\\\' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimµLate transcription throµgh the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:CAMK4 Research Areas:Epigenetics and Nuclear Signaling; Neuroscience; Signal transduction