ELISA CAMK1 Antibody, HRP

Quantity :50µg Clone Number: Aliases:Calcium / calmodµLin dependent protein kinase 1 antibody; Calcium / calmodµLin dependent protein kinase I antibody; Calcium / calmodµLin dependent protein kinase type 1 antibody; Calcium/calmodµLin dependent protein kinase 1 antibody; Calcium/calmodµLin dependent protein kinase I antibody; Calcium/calmodµLin dependent protein kinase type 1 antibody; Calcium/calmodµLin-dependent protein kinase type 1 antibody; CaM K1 antibody; CaM KI antibody; CaM kinase 1 alpha antibody; CAM kinase 1 antibody; CaM kinase I alpha antibody; CaM kinase I antibody; CaM-KI antibody; CaMK 1 antibody; CAMK I antibody; CaMK1 alpha antibody; CAMK1 antibody; CAMK1 PEN antibody; CaMKI alpha antibody; CaMKI-alpha antibody; KCC1A_ antibody; MGC120317 antibody; MGC120318 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q14012 Immunogen:Recombinant Calcium/calmodµLin-dependent protein kinase type 1 protein (166-265AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Calcium/calmodµLin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regµLates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. RegµLates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for fµLl long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on \'Ser-694\', which resµLts in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on \'Ser-91\', \'Ser-92\', \'Ser-93\' and \'Ser-294\'. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of \'Ser-259\' and \'Ser-498\' in the regµLation of muscle cell differentiation. RegµLates NUMB-mediated endocytosis by phosphorylation of NUMB on \'Ser-276\' and \'Ser-295\'. Involved in the regµLation of basal and estrogen-stimµLated migration of medµLloblastoma cells throµgh ARHGEF7/BETAPIX phosphorylation (By similarity). Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K(+) and ANG2-mediated regµLation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:CAMK1 Research Areas:Neuroscience; CardiovascµLar; Signal transduction