ELISA C4B Antibody, HRP

Quantity :50µg Clone Number: Aliases:Basic complement C4 antibody; C2B5 antibody; C3 and PZP-like alpha-2-macroglobµLin domain-containing protein 3 antibody; C4b antibody; C4B1 antibody; C4B2 antibody; C4B3 antibody; CO4B_ antibody; Complement C4 gamma chain antibody; Complement component 4B antibody; CPAMD3 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P0C0L5 Immunogen:Recombinant Complement C4-B protein (1454-1744AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Non-enzymatic component of the C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobµLins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC throµgh CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens. Ref.16 Ref.17 Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascµLar permeability and causes histamine release from mast cells and basophilic leukocytes. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:C4B Research Areas:Immunology