ELISA CDKN1A anti-

Quantity :50µL Clone Number: Aliases:CAP20 antibody; CDK-interacting protein 1 antibody; CDKI antibody; CDKN1 antibody; Cdkn1a antibody; CDN1A_ antibody; CIP1 antibody; Cyclin Dependent Kinase Inhibitor 1A antibody; Cyclin-dependent kinase inhibitor 1 antibody; Cyclin-dependent kinase inhibitor 1A (P21) antibody; Cyclin-dependent kinase inhibitor 1A (p21, Cip1) antibody; DNA Synthesis Inhibitor antibody; MDA-6 antibody; MDA6 antibody; Melanoma differentiation-associated protein 6 antibody; Melanoma differentiation-associated protein antibody; p21 antibody; P21 protein antibody; p21CIP1 antibody; p21Cip1/Waf1 antibody; p21WAF antibody; PIC1 antibody; SDI1 antibody; SLC12A9 antibody; WAF1 antibody; Wild type p53 activated fragment 1 (WAF1) antibody; Wild type p53 activated fragment 1 antibody; Wildtype p53-activated fragment 1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P38936 Immunogen:Fusion protein of CDKN1A Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB, IHC; ELISA:1:1000-1:5000, WB:1:200-1:1000, IHC:1:25-1:100 Background:This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regµLator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, throµgh which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimµLi. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regµLatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. MµLtiple alternatively spliced variants have been found for this gene. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen affinity purification Conjµgate:Non-conjµgated Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:CDKN1A Research Areas:Epigenetics and Nuclear Signaling;Cancer;Cell biology