ELISA AIM2 anti-

Quantity :100µL Clone Number: Aliases:Absent in melanoma 2 antibody; AIM 2 antibody; Aim2 antibody; AIM2_ antibody; Interferon-inducible protein AIM2 antibody; OTTHUMP00000035296 antibody; PYHIN4 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O14862 Immunogen:SyntheQuantityd peptide derived from internal of AIM2. Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB; WB:1:500-1:3000 Background:Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thoµght to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 By similarity. Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity. DeYoung K.L., Oncogene 15:453-457(1997). Gregory S.G., Nature 441:315-321(2006). Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:AIM2 Research Areas:Epigenetics and Nuclear Signaling;Cancer