ELISA CCNC (Ab-275) anti-

Quantity :100µL Clone Number: Aliases:ccnc antibody; CCNC_ antibody; CycC antibody; Cyclin C antibody; Cyclin-C antibody; hSRB11 antibody; OTTHUMP00000016897 antibody; SRB11 homolog antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P24863 Immunogen:SyntheQuantityd non-phosphopeptide derived from Cyclin C around the phosphorylation site of serine 275 (N-G-S(p)-Q-N). Raised in:Rabbit Reactivity:, Mouse Tested Applications:ELISA, WB; WB:1:500-1:3000 Background:Component of the Mediator complex, a coactivator involved in regµLated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regµLatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regµLatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Lew D.J., Cell 66:1197-1206(1991). Li H., Genomics 32:253-259(1996). Mungall A.J., Nature 425:805-811(2003). Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:CCNC Research Areas:Epigenetics and Nuclear Signaling;Cell biology